It is used as an alternative to warfarin and does not require monitoring. A quick reference book of formulas, charts, and tables. Request rx eliquis samples and get resources for hcps and patients. Evaluation of crushed tablet for oral administration and the effect of food on apixaban pharmacokinetics in healthy adults. Apixaban lowers stroke risk in atrial fibrillation. Apixaban is a substrate of pglycoprotein and breast cancer resistance protein, 2 efflux transporters located in the intestine, although consumption of applesauce or apple juice is. Realworld analysis compares safety, effectiveness of apixaban versus warfarin august 28, 2017 bristolmyers squibb company and pfizer inc. The nci drug dictionary contains technical definitions and synonyms for drugsagents used to treat patients with cancer or conditions related to cancer. Apixaban inhibits free and clotbound fxa, and prothrombinase activity. It works by decreasing the clotting ability of the blood and helps preventing harmful clots from forming in the blood vessels. Evaluation of crushed tablet for oral administration and.
Realworld analysis compares safety, effectiveness of. In case of emergency, this would be important for health care providers to know. Apixaban for treatment of embolic stroke of undetermined. The limited available data on eliquis use in pregnant women are insufficient to. The anticoagulant effect of apixaban can be expected to persist for at least 24 hours after the last dose i. Apixaban pharmacology, medicinal chemistry and drug design. Material safety data sheet of apixaban contains identification of substance and details of the supplier of the safety data sheet. Definition of apixaban nci drug dictionary national.
There are five oral anticoagulants licensed for use in the uk. Your doctor has prescribed apixaban to keep harmful blood clots from forming. Apixaban is another oral direct factor xa inhibitor with promising data. Wo2014072884a1 process for the synthesis of apixaban. Download our full product technical data book to find the right tyre for you. Apixaban is also used to prevent stroke and blood clots in patients with certain heart rhythm problem eg, nonvalvular atrial fibrillation. The present invention relates to the process for the preparation of apixaban and novel intermediates useful in the synthesis of apixaban i. Product technical data book michelin produces a wide range of tyres to handle various usage conditions and help you meet your productivity goals.
These new data from posthoc analyses from aristotle apixaban for reduction in stroke and other thromboembolic events in atrial. Amplify was a prospective, randomized, doubleblind trial that compared apixaban 10 mg twice daily for seven days reversal of anticoagulation in intracranial hemorrhage. Discontinue apixaban and begin both a parenteral anticoagulant and warfarin at the time the next dose of apix aban would have been taken. Uw medicine alternative monitoring for antithrombotic agents. Acropolis apixaban experience through realworld population studies is the eliquis apixaban global realworld data program designed to generate additional evidence from routine clinical practice settings to further inform healthcare decision makers, including healthcare providers and payers.
Apixaban patient medication guide anticoagulation services. Apixaban has no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin. Apixaban is not intended to be monitored using routine coagulation testing. The results have been positioned as the most positive yet for one of the new oral anticoagulants in af and appear to give apixaban the edge over its two major competitors, dabigatran pradaxa.
Safety and efficacy of apixaban in the treatment of atrial. Stopping apixaban abruptly without switching to another anticoagulant may increase your risk of stroke or blood clots. Apixaban is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis dvt, which can lead to blood clots in the lungs. Its fixed dosing is not intended to be adjusted on the basis of any coagulation laboratory parameter. Monitoring requirements apixaban will require monitoring. Please note that the information contained herein is not to be interpreted as an alternative to medical advice from your doctor or other professional healthcare provider. Always read the patient information leaflet in your medication package. The dose of apixaban is 5 mg twice daily as studied in the augustus trial. As a result of fxa inhibition, apixaban prolongs clotting tests such as prothrombin time pt inr, and activated partial thromboplastin time aptt. Thrombosis is a major cause of morbidity and mortality in the western world and plays a pivotal role in the pathogenesis of numerous cardiovascular disorders, including acute coronary syndrome acs i. A simple, robust, and stabilityindicating reversedphase highperformance liquid chromatographic hplc method for the analysis of apixaban and its related substances has been successfully developed. Patents listed in the fda orange book drug database of apixaban with information and expiryexpiration dates.
Patient information heet apixaban thrombosis canada. Apixabans dose is eliminated by hepatic metabolism, renal excretion, and gastrointestinalbile secretion, with each being responsible for approximately onethird of a dose. For more drug warnings complete data for apixaban 17 total, please visit the hsdb record page. Apixaban eliquis is an expensive drug used to lower the chance of stroke in people with a medical condition called atrial fibrillation. This handout explains the medicine apixaban, a drug that helps prevent blood clots. By continuing to browse this site you are agreeing to our use of cookies. Electronic orange bookapproved drug products with therapeutic equivalence. Apixaban is an orally active, selective, direct inhibitor of the coagulation factor xa fxa that reversibly and directly binds to the active site of fxa. Material safety data sheet of apixaban abmole bioscience.
Apixaban therapy may increase the risk of hemorrhage during pregnancy and obstetric delivery. Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation apixaban is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis, which can lead to blood clots in the lungs pulmonary embolism apixaban is also used to treat dvt or pulmonary. Apixaban is an orally bioavailable, selective inhibitor of both free and prothrombinasebound factor xa k i s 0. Each drug entry includes links to check for clinical trials listed in ncis list of cancer clinical trials. Apixaban is an oral, reversible, and selective active site inhibitor of fxa. Helping to treat deep vein thrombosis and pulmonary. For operating conditions which differ from these, please contact us. Pfe today announced the results of the phase 3 adopt apixaban dosing to optimize protection from thrombosis trial, which evaluated apixaban versus enoxaparin in acutely ill medical patients, did not meet the primary efficacy outcome of superiority to enoxaparin for the endpoint of venous. Find information on apixaban eliquis in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life. Apixaban is a factor xa inhibitor, an anticoagulant. Clinical data are lacking on the use of apixaban in patients.
In patients with at least 2 of the following characteristics. This technical data book is designed to provide the most important information, technical references and recommendations needed to help achieve the maximum service life of continental tires for both end users and manufacturers. Patients taking apixaban do require followup with their physician carrying a wallet card or id bracelet that states you are taking apixaban is a good idea. Among patients with atrial fibrillation, shortduration apixaban 48 hours is feasible compared with shortduration heparinwarfarin. Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. Identification of the substancemixture and of the companyundertaking product name. Among directacting oral anticoagulants doacs, apixaban was rated most efficient at treating atrial fibrillation in a metaanalysis comparing the drugs with each other and with warfarin. Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation. But the data reporting problems destroy our confidence. The data given in this guide is based on average operating conditions as are normally found in central europe. Apixaban was found to be comparable to warfarin in a small phase ii trial for the treatment of dvt. It does not require antithrombin iii for antithrombotic activity. Pfe announced today that 19 abstracts latebreaking, rapidfire, oral and poster presentations will be presented at esc congress 2016, to be held august 2731 in rome, italy.
Bristolmyers squibb and pfizer to present new data on. Bristolmyers squibb and pfizer present large realworld. Apixaban is a new chemical entity being d eveloped for the prevention and treatment of vte and for the prevention of stroke and systemic embolism in patients with atrial fibrillation af. Data on the use of apixaban is limited and insufficient to determine risks of major birth defects, miscarriage, or adverse developmental outcomes. Bristolmyers squibb and pfizer to present new eliquis. If you have any specific questions about any medical matter, you should consult your doctor or. Treatment may also increase the risk of bleeding in the fetus or neonate. Apixaban is an oral, direct factor xa inhibitor that inhibits both free and.
Apixaban affects inr, so inr measurements made during coadministration with warfarin may not be useful for determining the appropriate dose of warfarin. Eliquis apixaban dose, indications, adverse effects. Technical data book the information contained herein has been collected from various sources. Warfarin is a highly effective treatment in reducing this risk, but a narrow therapeutic range, drug and food interactions, required monitoring, and bleeding limit its use. Shortduration apixaban was associated with a lower frequency of stroke or systemic embolism and similar incidence of bleeds compared with heparinwarfarin. It is also used to treat or prevent clots in the lungs or in the veins. An agent to reverse the antifactor xa activity of apixaban is available.